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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7759337 B1

PDFFull Text
Date of Patent:
Jul. 20, 2010

Filed:

Mar. 02, 2006

Phthalazine compounds and methods of use

Applicants:

Andrew Tasker, Simi Valley, CA (US);

Dawei Zhang, Thousand Oaks, CA (US);

Guo-qiang Cao, Thousand Oaks, CA (US);

Partha Pratim Chakrabarti, Newbury Park, CA (US);

James Richard Falsey, Moorpark, CA (US);

Bradley J. Herberich, Newbury Park, CA (US);

Randall W. Hungate, Camarillo, CA (US);

Liping H. Pettus, Thousand Oaks, CA (US);

Anthony Reed, Oxnard, CA (US);

Robert M. Rzasa, Ventura, CA (US);

Kelvin K. C. Sham, Thousand Oaks, CA (US);

Maya C. Thaman, Ventura, CA (US);

Shimin Xu, Santa Barbara, CA (US);

Inventors:

Andrew Tasker, Simi Valley, CA (US);

Dawei Zhang, Thousand Oaks, CA (US);

Guo-Qiang Cao, Thousand Oaks, CA (US);

Partha Pratim Chakrabarti, Newbury Park, CA (US);

James Richard Falsey, Moorpark, CA (US);

Bradley J. Herberich, Newbury Park, CA (US);

Randall W. Hungate, Camarillo, CA (US);

Liping H. Pettus, Thousand Oaks, CA (US);

Anthony Reed, Oxnard, CA (US);

Robert M. Rzasa, Ventura, CA (US);

Kelvin K. C. Sham, Thousand Oaks, CA (US);

Maya C. Thaman, Ventura, CA (US);

Shimin Xu, Santa Barbara, CA (US);

Assignee:

Amgen Inc., Thousand Oaks, CA (US);

Attorney:

G. Prabhakar Reddy

Primary Examiner:

James O Wilson

Assistant Examiner:

Cecilia M Jaisle

Int. Cl.
CPC ...
C07D 237/34 (2006.01); C07D 413/12 (2006.01); C07D 498/08 (2006.01); C07D 279/12 (2006.01); C07D 243/08 (2006.01); A61K 31/498 (2006.01); A61K 31/5355 (2006.01); A61K 31/537 (2006.01); A61K 31/541 (2006.01); A61K 31/551 (2006.01); A61P 29/00 (2006.01); A61P 23/00 (2006.01); C07D 487/04 (2006.01); A61K 31/4985 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein B, R, R, R, Rand Rare d.efined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.

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