The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 20, 2010
Filed:
Apr. 23, 2007
Stefan Holdenrieder, Munich, DE;
Martin Busch, Emmering, DE;
Heinz Bodenmueller, Munich, DE;
Georg Fertig, Penzberg, DE;
Andreas Schalhorn, Planegg, DE;
Petra Stieber, Gauting, DE;
Stefan Holdenrieder, Munich, DE;
Martin Busch, Emmering, DE;
Heinz Bodenmueller, Munich, DE;
Georg Fertig, Penzberg, DE;
Andreas Schalhorn, Planegg, DE;
Petra Stieber, Gauting, DE;
Roche Diagnostics, , DE;
Abstract
The present invention concerns a method for the determination of apoptotic products in samples taken from patients in which apoptosis is induced as a result of disease or therapy, which is characterized in that the concentration of the apoptotic products in samples taken from patients is correlated with the effectiveness of the therapy and thus serves as a follow-up for the therapy. The present invention in particular concerns a method in which the concentration of nucleosomes is determined in serum samples of tumour patients in order to assess the effectiveness of tumour therapy. Furthermore the present invention also concerns the use of a method according to the invention to determine the effectiveness of therapy in tumour patients who are subjected to a radiotherapy or chemotherapy treatment as well as in patients after an acute ischaemic event or after hypothermia treatment.