The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 20, 2010
Filed:
Dec. 24, 2007
Applicants:
Craig E. Cameron, State College, PA (US);
Christian Castro, State College, PA (US);
Jamie J. Arnold, State College, PA (US);
Inventors:
Craig E. Cameron, State College, PA (US);
Christian Castro, State College, PA (US);
Jamie J. Arnold, State College, PA (US);
Assignee:
The Penn State Research Foundation, University Park, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/13 (2006.01); C12N 7/00 (2006.01); C12N 7/04 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention encompasses compositions and methods relating to viral polymerases having one or more substitutions of different amino acids at conserved regions of the polymerase yields enzymes with varying rates and fidelity of replication. A universally applicable, polymerase-mechanism-based strategy for production of attenuated viruses and anti-viral vaccines is disclosed.