The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 13, 2010
Filed:
Mar. 15, 2005
Che-ming Teng, Taipei, TW;
Jih-hwa Guh, Taipei, TW;
Shiow-lin Pan, Taipei, TW;
Sheng-chu Kuo, Taichung, TW;
Fang-yu Lee, Tachia Taichung, TW;
Che-Ming Teng, Taipei, TW;
Jih-Hwa Guh, Taipei, TW;
Shiow-Lin Pan, Taipei, TW;
Sheng-Chu Kuo, Taichung, TW;
Fang-Yu Lee, Tachia Taichung, TW;
Yung Shin Pharmaceutical Ind. Co., Ltd., Tachia, Taichung, TW;
Abstract
A method for preferentially inhibiting release of pro-inflammatory cytokines over release of anti-inflammatory cytokines using a fused pyrazolyl compound of formula (I): A is R or in which R is H, alkyl, aryl, cyclyl, heteroaryl, or heterocyclyl; each of Ar, Ar, and Ar, independently, is phenyl, thienyl, furyl, or pyrrolyl; each of R, R, R, R, R, and R, independently, is R', nitro, halogen, —C(O)—OR′, —C(O)—SR′, —C(O)—NR′R″, —(CH)OR′, —(CH)SR′, —(CH)NR′R″, —(CH)CN, —(CH)C(O)—OR′, —(CH)C(O)H, or Rand Rtogether, Rand Rtogether, or Rand Rtogether are —O(CH2)O—, in which each of R′ and R″, independently, is H, alkyl, cyclyl, aryl, heteroaryl, heterocyclyl; and m is 0, 1, 2, 3, 4, 5, or 6; and n is 1, 2, or 3. This invention also covers a method of inhibiting activity of NF-κB with such a compound.