The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 13, 2010

Filed:

Feb. 09, 2005
Applicants:

Nagasree Chakka, Burnaby, CA;

Mikhail Chafeev, Vancouver, CA;

Sultan Chowdhury, Scarborough, CA;

Jian-min Fu, Burnaby, CA;

Duanjie Hou, Burnaby, CA;

Rajender Kamboj, Burnaby, CA;

Vishnumurthy Kodumuru, Burnaby, CA;

Shifeng Liu, Port Coquitlam, CA;

Vandna Raina, Vancouver, CA;

Shaoyi Sun, Vancouver, CA;

Serguei Sviridov, Burnaby, CA;

Michael D. Winther, Vancouver, CA;

Zaihui Zhang, Vancouver, CA;

Melwyn Abreo, Jamul, CA;

Mark W. Holladay, San Diego, CA (US);

Wenbao LI, San Diego, CA (US);

Sengen Sun, San Diego, CA (US);

Chi Tu, San Diego, CA (US);

Heinz W. Gschwend, Santa Rosa, CA (US);

Inventors:

Nagasree Chakka, Burnaby, CA;

Mikhail Chafeev, Vancouver, CA;

Sultan Chowdhury, Scarborough, CA;

Jian-Min Fu, Burnaby, CA;

Duanjie Hou, Burnaby, CA;

Rajender Kamboj, Burnaby, CA;

Vishnumurthy Kodumuru, Burnaby, CA;

Shifeng Liu, Port Coquitlam, CA;

Vandna Raina, Vancouver, CA;

Shaoyi Sun, Vancouver, CA;

Serguei Sviridov, Burnaby, CA;

Michael D. Winther, Vancouver, CA;

Zaihui Zhang, Vancouver, CA;

Melwyn Abreo, Jamul, CA;

Mark W. Holladay, San Diego, CA (US);

Wenbao Li, San Diego, CA (US);

Sengen Sun, San Diego, CA (US);

Chi Tu, San Diego, CA (US);

Heinz W. Gschwend, Santa Rosa, CA (US);

Assignee:

Xenon Pharmaceuticals Inc., Burnaby, British Columbia, CA;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/551 (2006.01); A61K 31/5513 (2006.01); A61K 31/50 (2006.01); A61K 31/502 (2006.01); A61K 31/501 (2006.01); C07D 245/02 (2006.01); C07D 243/04 (2006.01); C07D 243/08 (2006.01); C07D 403/04 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); A61P 7/12 (2006.01);
U.S. Cl.
CPC ...
Abstract

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (Ia): where x, y, W, V, R, R, R, R, R, R, R, R, R, R, Rand Rare defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.


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