The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 13, 2010
Filed:
Jan. 03, 2008
Applicants:
Mario Contorni, Siena, IT;
Massimo Maffei, Siena, IT;
Inventors:
Mario Contorni, Siena, IT;
Massimo Maffei, Siena, IT;
Assignee:
Novartis Caccines and Diagnostics SRL, Siena, IT;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/02 (2006.01); A61K 39/38 (2006.01); A61K 39/116 (2006.01); C07K 14/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
To improve the stability of vaccines comprising aluminum salt(s), the invention uses the amino acid histidine. This can improve pH stability and adjuvant adsorption and can reduce antigen hydrolysis. Histidine is preferably present during adsorption to the aluminum salt(s). The antigen in the vaccine may be a protein or a saccharide and is preferably from