The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 06, 2010

Filed:

Sep. 26, 2003
Applicants:

Robert O. Dempcy, Kirkland, WA (US);

Alexander A. Gall, Woodinville, WA (US);

Sergey G. Lokhov, Kirkland, WA (US);

Irina A. Afonina, Mill Creek, WA (US);

Igor V. Kutyavin, Woodinville, WA (US);

Nicolaas M. J. Vermeulen, Woodinville, WA (US);

Inventors:

Robert O. Dempcy, Kirkland, WA (US);

Alexander A. Gall, Woodinville, WA (US);

Sergey G. Lokhov, Kirkland, WA (US);

Irina A. Afonina, Mill Creek, WA (US);

Igor V. Kutyavin, Woodinville, WA (US);

Nicolaas M. J. Vermeulen, Woodinville, WA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G06F 19/00 (2006.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
Abstract

Methods for designing an oligonucleotide sequence having a selected duplex stability are provided wherein the oligonucleotide portion comprises at least one modified base selected from universal bases, unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally having attached minor groove binders and reporter groups.


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