The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 06, 2010
Filed:
Jun. 05, 2006
Seongeun Cho, Hillsborough, NJ (US);
Davinder Singh Gill, Andover, MA (US);
Xiang Yang Tan, Reading, MA (US);
Ming Diana Qian, Sugar land, TX (US);
Seongeun Cho, Hillsborough, NJ (US);
Davinder Singh Gill, Andover, MA (US);
Xiang Yang Tan, Reading, MA (US);
Ming Diana Qian, Sugar land, TX (US);
Wyeth LLC, Madison, NJ (US);
Abstract
The present invention provides monoclonal antibodies for human TrkB. In certain embodiments the inventive antibodies bind and activate human TrkB. In certain embodiments the inventive antibodies are selective for human TrkB in that they do not bind (or activate) human TrkA or human TrkC. In some embodiments the inventive monoclonal antibodies cross-react with murine TrkB. Humanized or veneered versions of the inventive antibodies are also encompassed. Pharmaceutical compositions that comprise inventive antibodies are provided as are methods for preparing the inventive antibodies and methods of using these for treatment, detection or purification purposes.