The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 06, 2010
Filed:
Jan. 19, 2005
Tai-wei Ly, San Diego, CA (US);
Takashi Yoshino, Saitama, JP;
Yuki Takekawa, Kyoto, JP;
Takuya Shintani, Kyoto, JP;
Hiromi Sugimoto, Kyoto, JP;
Kevin Bacon, San Diego, CA (US);
Klaus Urbahns, Lund, SE;
Tai-Wei Ly, San Diego, CA (US);
Takashi Yoshino, Saitama, JP;
Yuki Takekawa, Kyoto, JP;
Takuya Shintani, Kyoto, JP;
Hiromi Sugimoto, Kyoto, JP;
Kevin Bacon, San Diego, CA (US);
Klaus Urbahns, Lund, SE;
Actimis Pharmaceuticals, Inc., San Diego, CA (US);
Abstract
The present invention relates to an imidazo[1,2-c]pyrimidinylacetic acid derivative and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The imidazo[1,2-c]pyrimidinylacetic acid derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.