The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 06, 2010
Filed:
Apr. 09, 2004
Irving W. Wainer, Washington, DC (US);
Krzysztof Jozwiak, Abingdon, MD (US);
Ruin Moaddel, Germantown, MD (US);
Sarangan Ravichandran, Frederick, MD (US);
Jack R. Collins, Frederick, MD (US);
Irving W. Wainer, Washington, DC (US);
Krzysztof Jozwiak, Abingdon, MD (US);
Ruin Moaddel, Germantown, MD (US);
Sarangan Ravichandran, Frederick, MD (US);
Jack R. Collins, Frederick, MD (US);
Abstract
A computer readable medium holding data of a molecular model of a ligand-gated ion channel receptor and/or a computer system for modeling said receptor are provided by the instant invention. The molecular model can be used to design novel compounds having activity as non-competitive inhibitors of the ion channel. A preferred embodiment of the invention relates to nicotinic acetylcholine receptors. Compounds having activity as non-competitive inhibitors of ligand-gated ion channel receptors and methods for inhibiting the receptor and treating diseases or disorders mediated by function of the receptor are also disclosed.