The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 29, 2010

Filed:

Feb. 10, 2009
Applicants:

Ljubomir J. Buturovic, East Palo Alto, CA (US);

Glenda G. Anderson, San Jose, CA (US);

Inventors:

Ljubomir J. Buturovic, East Palo Alto, CA (US);

Glenda G. Anderson, San Jose, CA (US);

Assignee:

Pathwork Diagnostics, Inc., Redwood City, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G06F 15/18 (2006.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
Abstract

Apparatus, systems and methods for determining, for each respective phenotypic characterization in a set of {T, . . . , T} characterizations, that a test specimen has the respective characterization are provided. A pairwise probability function g(X, W), for a phenotypic pair (T, T) in {T, . . . , T} is learned using a training population. Wis a set of parameters derived from Y for (T, T) by substituting each Yin Y into g(X, W), as X, where Yis the set of cellular constituent abundance values from sample i in the training population exhibiting Tor T. The learning step is repeated for each (T, T) in {T. . . , T}, thereby deriving pairwise probability functions G={g(X, W), . . . , g(X, W)}. Pairwise probability values P={p, . . . , p} are computed, where each pis equal to g(Z, W) in G, the probability that the test specimen has Tand not T, where Z is cellular constituent abundance values of the test specimen.


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