The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 29, 2010
Filed:
Dec. 12, 2006
Robert V. Farese, Jr., Kentfield, CA (US);
Hubert C. Chen, Newbury Parl, CA (US);
Steven J. Smith, San Francisco, CA (US);
Sylvaine Cases, Belmont, CA (US);
Sandra K. Erickson, San Francisco, CA (US);
Robert V. Farese, Jr., Kentfield, CA (US);
Hubert C. Chen, Newbury Parl, CA (US);
Steven J. Smith, San Francisco, CA (US);
Sylvaine Cases, Belmont, CA (US);
Sandra K. Erickson, San Francisco, CA (US);
The Regents of the University of California, Oakland, CA (US);
The United States of America as represented by the Department of Veterans Affairs, Washington, DC (US);
The J. David Gladstone Institutes, San Francisco, CA (US);
Abstract
Methods and compositions for modulating carbohydrate metabolism in a host are provided. In the subject methods, diacylglycerol acyltransferase (DGAT) activity (specifically DGAT1 activity) is modulated, e.g., reduced or enhanced, to achieve a desired insulin and/or leptin sensitivity, thereby modulating carbohydrate metabolism, e.g., increasing or decreasing blood glucose levels, glucose uptake into cells and assimilation into glycogen. Also provided are pharmaceutical compositions for practicing the subject methods. The subject methods and compositions find use in a variety of applications, including the treatment of hosts suffering conditions associated with abnormal carbohydrate metabolism, such as obesity or diabetes.