The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 29, 2010
Filed:
Sep. 27, 2004
Jan Zygmunt, Longmont, CO (US);
James Ferrara, Boulder, CO (US);
James D. Mcchesney, Boulder, CO (US);
Jan Zygmunt, Longmont, CO (US);
James Ferrara, Boulder, CO (US);
James D. McChesney, Boulder, CO (US);
Tapestry Pharmaceuticals, Inc, Boulder, CO (US);
Abstract
The present invention relates to taxane analogs for the treatment of cancer having the general formula: wherein Rand Rare each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; Ris hydroxyl or OP; Rand Rare each hydroxyl or RCOO; Ris hydroxyl, OP, RCOO, or an ether functionality; Ris an alkyl group, an olefinic group, or an aromatic group; Pand Pare each hydroxyl protecting groups; Rand Rare each selected from H, alkyl group, olefinic or aromatic group. The present invention is also directed to production methods and intermediates useful in the formation of these new taxane analogs. The methods may begin with a starting compound, such as paclitaxel or docetaxel, which is converted into a taxane analog through various intermediate compounds.