The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 29, 2010
Filed:
Dec. 30, 2003
Thor Grundtvig Theander, Ishøj, DK;
Ali Salanti, Copenhagen, DK;
Lars Hviid, Copenhagen S, DK;
Trine Staalsø, Copenhagen NV, DK;
Anja Tatiana Ramstedt Jensen, Brønshøj, DK;
Thomas Lavstsen, Copenhagen Ø, DK;
Madelaine Dahlbäck, Malmö, SE;
Thor Grundtvig Theander, Ishøj, DK;
Ali Salanti, Copenhagen, DK;
Lars Hviid, Copenhagen S, DK;
Trine Staalsø, Copenhagen NV, DK;
Anja Tatiana Ramstedt Jensen, Brønshøj, DK;
Thomas Lavstsen, Copenhagen Ø, DK;
Madelaine Dahlbäck, Malmö, SE;
Kobenhavns Universitet, Copenhagen, DK;
Abstract
The present invention relates to nucleic acid molecules related to the var2csa gene family as well as amino acid sequences encoded by such nucleic acid molecules with respect to their role in mediating adhesion of infected red blood cells to chondroitin sulphate A (CSA) in the placenta which is characteristic for the pathogenesis of pregnancy associated malaria (PAM). Accordingly, The invention provides the use compounds that are related to VAR2CSA polypeptides var2csa nucleic acid molecules as medicaments, as well as it provides pharmaceutical compositions, in particular immunological compositions and vaccines, hereunder nucleotide-based vaccines comprising these compounds. In addition, the invention provides the use of the compounds mentioned for the manufacture of compositions, such as immunogenic compositions. Other aspects of the invention relates to methods of treatment and prevention of pregnancy associated malaria wherein these methods are based on the nucleic acid molecules and polypeptides the invention. As these compounds can also be used as biotechnological tools the invention provides in vitro diagnostic methods and kits comprising reagents and IgGs/antibodies designated to the use in such methods. The invention also relates to methods of identifying agents capable of modulating the VAR2CSA dependent adhesion to CSA and agent capable of interacting with VAR2CSA. Finally, a method for identifying polypeptides, which will induce a specific IgG/antibody response upon administration to a subject is provided by the invention.