The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 29, 2010
Filed:
Jun. 27, 2005
Stephanie Mouhat, Chelles, FR;
Jean-marc Sabatier, Rousset, FR;
Bonabes Olivier DE Rouge, Paris, FR;
Stephanie Mouhat, Chelles, FR;
Jean-Marc Sabatier, Rousset, FR;
Bonabes Olivier de Rouge, Paris, FR;
Cellpep Pharma Inc., , CA;
Abstract
OsK1 is a 38-residue peptide with 3 disulphide bridges and is found in the venom of the scorpion. It is potently active on voltage-gated Kchannels Kv1.1, Kv1.2 and Kv1.3, and moderately active on the type 1 intermediate-conductance Cat-activated channel K3.1. Derivatives of OsK1, particularly involving truncation or point mutations, have been developed to enhance the activity against and selectivity for the Kv1.3 channel. This renders the derivatives likely candidates for the treatment of autoimmune diseases, including multiple sclerosis. Such use may be alone or in combination therapy with maurotoxin, another scorpion toxin.