The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 29, 2010
Filed:
May. 11, 2006
Arnold Satterthwait, San Diego, CA (US);
Xiao-kun Zhang, San Diego, CA (US);
Xiuwen Zhu, San Diego, CA (US);
Siva Kolluri, San Diego, CA (US);
Arnold Satterthwait, San Diego, CA (US);
Xiao-kun Zhang, San Diego, CA (US);
Xiuwen Zhu, San Diego, CA (US);
Siva Kolluri, San Diego, CA (US);
The Burnham Institute, La Jolla, CA (US);
Abstract
Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing or preventing apoptosis are described, together with methods for identifying molecules that induce or prevent apoptosis through interaction with Bcl-2-family members. Methods for treatment of proliferative diseases and neurodegenerative diseases using the modulators of Bcl-2 and related family members are also disclosed.