The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 29, 2010
Filed:
Jun. 01, 2005
Craig Johnstone, Macclesfield, GB;
Darren Mckerrecher, Macclesfield, GB;
Kurt Gordon Pike, Macclesfield, GB;
Michael James Waring, Macclesfield, GB;
Craig Johnstone, Macclesfield, GB;
Darren McKerrecher, Macclesfield, GB;
Kurt Gordon Pike, Macclesfield, GB;
Michael James Waring, Macclesfield, GB;
AstraZeneca AB, Sodertalje, SE;
Abstract
Compounds of Formula (I) wherein: Ris hydroxymethyl; Ris selected from —C(O)NRR, SONRR, S(O)Rand HET-2; HET-1 is a 5- or 6-membered, optionally substituted C-linked heteroaryl ring; HET-2 is a 4-, 5- or 6-membered, C- or N-linked optionally substituted heterocyclyl ring; Ris selected from halo, fluoromethyl, difluoromethyl, trifluoromethyl, methyl, methoxy and cyano; Ris selected from for example hydrogen, optionally substituted (1-4C)alkyl and HET-2; Ris hydrogen or (1-4C)alkyl; or Rand Rtogether with the nitrogen atom to which they are attached may form a heterocyclyl ring system as defined by HET-3; HET-3 is for example an optionally substituted N-linked, 4, 5 or 6 membered, saturated or partially unsaturated heterocyclyl ring; p is (independently at each occurrence) 0, 1 or 2; m is 0 or 1; n is 0, 1 or 2; provided that when m is 0, then n is 1 or 2; or a salt, pro drug or solvate thereof, are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.