The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 29, 2010
Filed:
Dec. 21, 2006
Udo Bauer, Mölndal, SE;
Wayne Brailsford, Mölndal, SE;
Linda Gustafsson, Mölndal, SE;
Tor Svensson, Mölndal, SE;
Maria Saxin, Mölndal, SE;
Udo Bauer, Mölndal, SE;
Wayne Brailsford, Mölndal, SE;
Linda Gustafsson, Mölndal, SE;
Tor Svensson, Mölndal, SE;
Maria Saxin, Mölndal, SE;
AstraZeneca AB, Sodertalje, SE;
Abstract
The present invention relates to novel imidazole derivatives having a positive allosteric GABAB receptor (GBR) modulator effect, methods for the preparation of said compounds and to their use, optionally in combination with a GABAB agonist, for the inhibition of transient lower esophageal sphincter relaxations, for the treatment of gastroesophageal reflux disease, as well as for the treatment of functional gastrointestinal disorders and irritable bowel syndrome (IBS). The compounds are represented by the general formula (I) wherein R, R, Rand Y are as defined in the description. For example, Rmay be phenyl, Rmay be dimethylamino, Rmay be alkoxy and Y may be a thioylamino- or methyl eneamino- linked substitutuent containing an aryl group.