The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 29, 2010
Filed:
Nov. 15, 2006
Kwon Ho Kim, Palisades Park, NJ (US);
Paramjeet Kaur, Parsippany, NJ (US);
Jae Hoon JO, Deejeon, KR;
Myoung Ki Baek, Daejeon, KR;
Yeo Joo Yuk, Seoul, KR;
Kwon Ho Kim, Palisades Park, NJ (US);
Paramjeet Kaur, Parsippany, NJ (US);
Jae Hoon Jo, Deejeon, KR;
Myoung Ki Baek, Daejeon, KR;
Yeo Joo Yuk, Seoul, KR;
SK Holdings Co., Ltd., Seoul, KR;
Abstract
Disclosed herein is a transnasal anticonvulsive pharmaceutical composition comprising diazepam as an active ingredient, water, a fatty acid ester, diethylene glycol monoethyl ether, ethanol and sodium glycocholate, wherein the weight of the fatty acid ester is at least 2-fold higher than that of water and is at least 2-fold higher than that of ethanol. The anticonvulsive pharmaceutical composition for transmucosal delivery of diazepam according to the present invention includes a minimized content of water and ethanol, a fatty acid ester as a main ingredient and no use of a polar solvent, e.g. glycol, and, exhibits improved diazepam solubility and transmucosal permeability due to using a small amount of water and ethanol. The present invention also includes treatment of convulsions by transnasally administering to a patient in need thereof a therapeutically effective amount of the disclosed compositions.