The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 29, 2010
Filed:
Nov. 27, 2003
Akifumi Okuda, Ibaraki, JP;
Satoshi Yamamoto, Ibaraki, JP;
Takashi Sakai, Ibaraki, JP;
Susumu Takeda, Shizuoka, JP;
Takashi Nakashima, Kanagawa, JP;
Katsura Kaneko, Shizuoka, JP;
Tomohiro Sameshima, Shizouka, JP;
Taira Kato, Shizuoka, JP;
Naoto Kawamura, Kanagawa, JP;
Akifumi Okuda, Ibaraki, JP;
Satoshi Yamamoto, Ibaraki, JP;
Takashi Sakai, Ibaraki, JP;
Susumu Takeda, Shizuoka, JP;
Takashi Nakashima, Kanagawa, JP;
Katsura Kaneko, Shizuoka, JP;
Tomohiro Sameshima, Shizouka, JP;
Taira Kato, Shizuoka, JP;
Naoto Kawamura, Kanagawa, JP;
Mercian Corporation, Tokyo, JP;
Eisai R&D Management Co., Ltd., Tokyo, JP;
Abstract
The present invention provides a novel method of producing the 12-membered ring macrolide compound 11107D having an antitumor activity by biological transformation. Starting material which is the 12-membered ring macrolide compound 11107B represented by the formula (I) is incubated in the presence of a strain belonging to the genus, the genusor the family Micromonosporaceae (for example,sp. AB-1704 strain (FERM BP-8551)), each of which has the ability of transforming the 12-membered ring macrolide compound 11107B into a 11107D substance represented by the formula (II), or a preparation of its cultured myceha and oxygen, and then 11107D substance which is a target material is collected from the treating solution.