The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 29, 2010
Filed:
Oct. 26, 2007
William M. Ainley, Carmel, IN (US);
Janna Armstrong, Indianapolis, IN (US);
Krishna Madduri, Westfield, IN (US);
Donald J. Merlo, Carmel, IN (US);
Kelley A. Smith, Lebanon, IN (US);
Mark A. Thompson, Zionsville, IN (US);
Steven R. Webb, Westfield, IN (US);
Liu Y. Shen, Westfield, IN (US);
William M. Ainley, Carmel, IN (US);
Janna Armstrong, Indianapolis, IN (US);
Krishna Madduri, Westfield, IN (US);
Donald J. Merlo, Carmel, IN (US);
Kelley A. Smith, Lebanon, IN (US);
Mark A. Thompson, Zionsville, IN (US);
Steven R. Webb, Westfield, IN (US);
Liu Y. Shen, Westfield, IN (US);
Dow AgroSciences LLC, Indianpolis, IN (US);
Abstract
This invention pertains in part to the development of a vaccine for poultry against necrotic enteritis (NE). The vaccine utilizes a protective antigen that is a mutated, full-length, non-toxic(Cp) α-toxin protein (Mcpa). Utility of this vaccine was demonstrated by reduction of lesion severity in NE challenge trails, for example. Also disclosed herein are novel approaches for producing this vaccine in significant quantities. One exemplified approach involves producing NE vaccine (mutated alpha toxin) in bacterial expression systems, preferably utilizing thesystem, for commercial use in controlling NE in the poultry industry. The subject vaccines can be administered preferably to chickens in several different ways. A novel, Type VI alpha toxin from chicken isolates of Cp is also disclosed.