The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 29, 2010
Filed:
Jun. 13, 2003
Carl June, Merion Station, PA (US);
James Riley, Downingtown, PA (US);
Marcela Maus, Wynnewood, PA (US);
Anna Thomas, Freiburg, DE;
Robert Vonderheide, Merion Station, PA (US);
Carl June, Merion Station, PA (US);
James Riley, Downingtown, PA (US);
Marcela Maus, Wynnewood, PA (US);
Anna Thomas, Freiburg, DE;
Robert Vonderheide, Merion Station, PA (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
Provided are a system and methods for selectively inducing expansion of a population of T cells in the absence of exogenous growth factors, such as lymphokines, and accessory cells for research purposes. The cell based expansion system and methods permit the long-term growth of CTLs, preferably human CTLs. In addition, T cell proliferation can be induced without the need for antigen, thus providing an expanded T cell population that is polyclonal with respect to antigen reactivity. Further provided are methods for using the system and methods to screen and identify antigens related to specific diseases or conditions, tumors, autoimmune disorders, or an infectious disease or pathogen, and to identify target molecule for research purposes, or for developing a vaccine based thereon.