The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 29, 2010
Filed:
Apr. 20, 2006
Rolando Pérex Rodriguez, Habana, CU;
Gisela Maria González Marinello, Ciudad De La Habana, CU;
Tania Crobet Ramos, Ciudad Habana, CU;
Irene Beausoleil Del Gado, Ciudad De La Habana, CU;
Rolando Pérex Rodriguez, Habana, CU;
Gisela Maria González Marinello, Ciudad De La Habana, CU;
Tania Crobet Ramos, Ciudad Habana, CU;
Irene Beausoleil Del Gado, Ciudad De La Habana, CU;
Centro De Inmunologia Molecular, Ciudad de la Habana, CU;
Abstract
The present invention is related to the field of immunology and more specifically to cancer immunotherapy, particularly with immunotherapeutic combinations and treatment methods to prevent tumor cell growth and/or to eliminate those cells. The methods described in the present invention are based on the blockade of receptors with protein kinase activity in tyrosine residues (Receptor Tyrosine Kinases, RTK) and of ligands for those receptors. Immunotherapeutic combinations are described that cause the blockade of RTK receptors and/or their ligands, by means of a combination of passive and active immunotherapy. The referenced procedures can be applied to patients in different clinical stages with tumors of epithelial origin that over-express those receptors. The combination of active and passive immunotherapy can be simultaneous or sequential independent of whether the therapeutic procedure will be used in patients with advanced disease or as adjuvant therapy.