The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 29, 2010
Filed:
Jul. 16, 2007
Stephen Gregory Dimagno, Lincoln, NE (US);
Haoran Sun, Lincoln, NE (US);
Stephen Gregory DiMagno, Lincoln, NE (US);
Haoran Sun, Lincoln, NE (US);
Board Of Regents Of The University Of Nebraska, Lincoln, NE (US);
Abstract
The present invention is directed to a method for preparing an anhydrousF-radiolabeled fluorinating agent by a nucleophilic reaction of a hydratedF-radiolabeled fluoride ion source with an unsaturated carrier compound; treating theF-radiolabeled carrier compound to produce a non-aqueous mixture of theF-radiolabeled carrier compound in a solvent; and reacting theF-radiolabeled carrier compound with a nucleophilic composition in a nucleophilic reaction to produce an anhydrousF-radiolabeled fluorinating agent. The present invention is also directed to an anhydrousF-radiolabeled fluorinating agent comprising the formula [QM](F). Additionally, the present invention is directed to anF-radiolabeled fluorinated radiopharmaceutical or anF-radiolabeled fluorinated radiotracer prepared by reacting the anhydrousF-radiolabeled fluorinating agent with a drug intermediate. The present invention is further directed to methods for treating a disease or imaging a subject using anF-radiolabeled fluorinated radiopharmaceutical or anF-radiolabeled fluorinated radiotracer.