The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2010
Filed:
Aug. 25, 2003
Daniel C. Sigg, St. Paul, MN (US);
Daisy P. Cross, Minneapolis, MN (US);
Jesus W. Casas-bejar, Brooklyn Park, MN (US);
Rodolfo A. Padua, Richfield, MN (US);
Daniel C. Sigg, St. Paul, MN (US);
Daisy P. Cross, Minneapolis, MN (US);
Jesus W. Casas-Bejar, Brooklyn Park, MN (US);
Rodolfo A. Padua, Richfield, MN (US);
Medtronic, Inc., Minneapolis, MN (US);
Abstract
In general, the invention is directed to techniques for delivering macromolecules to a tissue site via electroporation. Particularly, a catheter detects contact between a distal end of the catheter and a target tissue site via a sensing electrode at the distal end of the catheter. The catheter delivers a fluid containing macromolecules to the tissue site upon detecting contact between the tissue site and the catheter. Concurrently or soon after delivery of the fluid, an electrical stimulus is applied to the tissue site. The electrical stimulus can be applied by the catheter or directly from a power supply, such as an implanted pulse generator. The electrical stimulus causes membranes of cells within the tissue site to destabilize, in turn, forming pores through which the macromolecules migrate into the cells of the tissue site.