The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2010
Filed:
Feb. 05, 2007
Robert W Brueggemeier, Dublin, OH (US);
Bin Su, Columbus, OH (US);
Edgar S Diaz-cruz, Columbus, OH (US);
Serena Landini, Columbus, OH (US);
Robert W Brueggemeier, Dublin, OH (US);
Bin Su, Columbus, OH (US);
Edgar S Diaz-Cruz, Columbus, OH (US);
Serena Landini, Columbus, OH (US);
The Ohio State University Research Foundation, Columbus, OH (US);
Abstract
Compounds and methods suppressing aromatase activity expression in cancer cells. Provided are compounds are those of formula I: wherein Rmay be alkyl, cycloalkyl, haloalkyl, aryl, substituted aryl, haloaryl, alkoxy, alkylaryl, and arylalkyl; Ris H, alkyl, aryl, alkylaryl, arylalkyl, and cycloalkyl; R, with the base nitrogen, forms an amide or sulfonamide; Ris selected from nitro, amine, amide, and benzamide; or a pharmaceutically acceptable salts thereof. Also provided are small molecule selective aromatase inhibitors having a molecular weight of less 500 g/mol. In some embodiments, the small molecule selective aromatase inhibitors described herein have a molecular weight of less than 450 g/mol. Also provided are methods for suppressing aromatase activity expression in cancer cells comprising the step of administering a pharmaceutically effective amount of a small molecule aromatase inhibitor to a subject in need of such treatment. In one embodiment, the cancer cells are breast cancer cells.