The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2010
Filed:
Nov. 29, 2007
Patrick Shum, Flemington, NJ (US);
Alexandre Gross, Jersey City, NJ (US);
Liang MA, Hillsborough, NJ (US);
Daniel G. Mcgarry, Branchburg, NJ (US);
Gregory H. Merriman, Phillipsburg, NJ (US);
David Rampe, Bernardsville, NJ (US);
Garth Ringheim, Belle Mead, NJ (US);
Jeffrey Stephen Sabol, Bridgewater, NJ (US);
Francis A. Volz, Neshanic Station, NJ (US);
Patrick Shum, Flemington, NJ (US);
Alexandre Gross, Jersey City, NJ (US);
Liang Ma, Hillsborough, NJ (US);
Daniel G. McGarry, Branchburg, NJ (US);
Gregory H. Merriman, Phillipsburg, NJ (US);
David Rampe, Bernardsville, NJ (US);
Garth Ringheim, Belle Mead, NJ (US);
Jeffrey Stephen Sabol, Bridgewater, NJ (US);
Francis A. Volz, Neshanic Station, NJ (US);
Aventis Pharmaceuticals Inc., Bridgewater, NJ (US);
Abstract
The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: wherein R, R, R, R, R, R, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer's disease, etc.