The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2010
Filed:
Sep. 11, 2003
Tetsushi Taguchi, Tsukuba, JP;
Hisatoshi Kobayashi, Tsukuba, JP;
Junzo Tanaka, Tsukuba, JP;
Hirofumi Saito, Tokyo, JP;
Tetsushi Taguchi, Tsukuba, JP;
Hisatoshi Kobayashi, Tsukuba, JP;
Junzo Tanaka, Tsukuba, JP;
Hirofumi Saito, Tokyo, JP;
National Institute for Materials Science, Tsukuba-shi, JP;
Furuuchi Chemical Corporation, Tokyo, JP;
Abstract
The crosslinking agents and condensing agents that have been employed in biological adhesives and in treating medical devices such as cardiac valves are non-natural compounds synthesized artificially. Thus, they are not metabolized in vivo and exhibit toxicity to living bodies. These compounds are thus used only in a restricted amount and for limited purposes in the clinical sites. The present invention provides a biological low-molecular-weight derivative obtained by modifying carboxyl groups of a biological low-molecular-weight compound with N-hydroxysuccinimide, N-hydroxysulfosuccinimide, or a derivative thereof and a crosslinked high-molecular-weight product obtained by crosslinking various high-molecular-weight compounds with this derivative.