The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2010
Filed:
Mar. 14, 2005
Vijay K. Kuchroo, Newton, MA (US);
Sumone Chakravarti, Oakland, CA (US);
Terry Strom, Brookline, MA (US);
Xin Xiao Zheng, Wellesley, MA (US);
Jennifer Meyers, Brighton, MA (US);
Vijay K. Kuchroo, Newton, MA (US);
Sumone Chakravarti, Oakland, CA (US);
Terry Strom, Brookline, MA (US);
Xin Xiao Zheng, Wellesley, MA (US);
Jennifer Meyers, Brighton, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Beth Israel Deaconess Medical Center, Inc., Boston, MA (US);
Abstract
The invention relates to methods of modulating immune responses in a subject, such as by administering to the subject agents which modulate tim-1, tim-2 or tim-4 activity, or which modulate the physical interaction between tim-1 and tim-4 or between tim-2 and a tim-2 ligand. Immune responses include, but are not limited to, autoimmune disorders, transplantation tolerance, and Th1 and Th2-mediated responses and disorders. The invention also relates to novel assays for identifying agents which modulate the physical interaction between tim-1 and tim-4. In addition, the invention relates to novel soluble tim-4 polypeptides and to nucleic acids which encode them.