The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2010
Filed:
Dec. 09, 2005
Applicants:
Charles W. Eigenbrot, Jr., Burlingame, CA (US);
Daniel K. Kirchhofer, Los Altos, CA (US);
Inventors:
Charles W. Eigenbrot, Jr., Burlingame, CA (US);
Daniel K. Kirchhofer, Los Altos, CA (US);
Assignee:
Genentech, Inc., San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/64 (2006.01); C12Q 1/37 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present disclosure provides crystals of and structural coordinates of Hepatocyte growth factor activator with and without bound pseudo-substrate or inhibitor. In a specific embodiment, a crystal structure of activated HGFA complexed with a Kunitz domain inhibitor is provided. The crystals and crystal structures are useful, for example, in the design and synthesis of inhibitors of HGFA.