The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2010
Filed:
Sep. 28, 2007
Michael J. Gerdes, Albany, NY (US);
Anup Sood, Clifton Park, NY (US);
Michael Christopher Montalto, Albany, NY (US);
Ali Can, Troy, NY (US);
Fiona Ginty, Saratoga Springs, NY (US);
Maureen Ann Bresnahan, Niskayuna, NY (US);
Robert John Filkins, Niskayuna, NY (US);
Zhengyu Pang, Clifton Park, NY (US);
Michael J. Gerdes, Albany, NY (US);
Anup Sood, Clifton Park, NY (US);
Michael Christopher Montalto, Albany, NY (US);
Ali Can, Troy, NY (US);
Fiona Ginty, Saratoga Springs, NY (US);
Maureen Ann Bresnahan, Niskayuna, NY (US);
Robert John Filkins, Niskayuna, NY (US);
Zhengyu Pang, Clifton Park, NY (US);
General Electric Company, Niskayuna, NY (US);
Abstract
Methods for probing multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one fluorescent probe to one or more target present in the sample, and binding at least at least one control probe to one or more target present in the sample. The methods include the steps of observing a signal from the fluorescent probe and a control signal from the control probe and applying to the sample a basic solution containing an oxidizing agent that selectively inactivates the fluorescent probe and not the control probe. The methods further include the steps of binding at least one fluorescent probe to one or more target present in the sample and observing a signal from the fluorescent probe. The methods disclosed herein also provide for multiple iterations of binding, observing, and oxidizing for deriving information about multiple targets in a single sample. An associated kit is also provided.