The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2010
Filed:
Mar. 07, 2002
Andre Schuh, Toronto, Ontario, CA;
Willem Ouwehand, Islington, London, N1 1BZ, GB;
Andre Schuh, Toronto, Ontario, CA;
Willem Ouwehand, Islington, London, N1 1BZ, GB;
Other;
Abstract
Based on the discovery of the nucleotide and amino acid differences which distinguish the Govand Govallelic forms of the membrane glycoprotein CD109, and which comprise the biallelic Gov platelet alloantigen system, compositions and methods are provided for determining the Gov genotype and phenotype of individuals. Also provided, on the basis of this discovery, are compositions and methods for treating disorders associated with Gov alloantigen incompatibility, such as the bleeding disorders post-transfusion purpura, post-transfusion platelet refractoriness, and neonatal alloimmune thrombocytopenia. The two allelic forms of CD109 differ by a single amino acid. The Govallelic form has Tyr at amino acid position 703 in the CD109 sequence. The Govallelic form has Ser at the same position. This amino acid difference is due to a single change, from A for the Govallele to C for the Govallele, in the CD109 gene.