The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 15, 2010
Filed:
Nov. 06, 2002
Lorant Gyuricza, Nyekljdhiza, HU;
Erszebet Meszaros-sos, Debrecen, HU;
Csaba Szabo, Debrecen, HU;
Claude Singer, Kfar Saba, IL;
Lorant Gyuricza, Nyekljdhiza, HU;
Erszebet Meszaros-Sos, Debrecen, HU;
Csaba Szabo, Debrecen, HU;
Claude Singer, Kfar Saba, IL;
TEVA Gyógyszergyár Zártkörüen Müködö Részvénytárasaság, Debrecen, HU;
Abstract
Processes are provided for preparing mupirocin calcium dihydrate from pseudomonic acid in a two phase system by using an organic carboxylate. A highly pure composition of amorphous mupirocin calcium is provided, and processes for its preparation by solvent removal, lyophilization and precipitation with use of an anti-solvent. Pharmaceutical compositions of amorphous form, and methods of using them to treat infections are also provided. Also provided are combined processes for preparing mupirocin calcium dihydrate and amorphous, by producing amorphous form first, followed by conversion of amorphous form into the dihydrate through crystallization from an aqueous solution. Also provided are processes for removing the water of crystallization of the dihydrate to obtain mupirocin calcium anhydrate.