The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 15, 2010

Filed:

Dec. 20, 2004
Applicants:

Zhiyong Luo, New York, NY (US);

Deborah H Slee, Cardiff, CA (US);

John Williams, San Diego, CA (US);

Inventors:

Zhiyong Luo, New York, NY (US);

Deborah H Slee, Cardiff, CA (US);

John Williams, San Diego, CA (US);

Assignee:

Smithkline Beecham (Cork) Limited, Currabinny, Carrigaline, County Cork, IE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61P 25/24 (2006.01); A61P 25/22 (2006.01);
U.S. Cl.
CPC ...
Abstract

CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm blooded animals, such as stroke. The CRF receptor antagonists of this invention have the following structure (I), including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, Y, Ar, and het are as defined herein. Compositions containing a CRF receptor antagonist in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods for use of the same.


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