The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 15, 2010
Filed:
Dec. 22, 2009
Applicants:
Jie Lin, West Roxbury, MA (US);
Bin Feng, N. Reading, MA (US);
Murray Robinson, Boston, MA (US);
Feng Jiang, Natick, MA (US);
Xiaojian Sun, Cambridge, MA (US);
Inventors:
Jie Lin, West Roxbury, MA (US);
Bin Feng, N. Reading, MA (US);
Murray Robinson, Boston, MA (US);
Feng Jiang, Natick, MA (US);
Xiaojian Sun, Cambridge, MA (US);
Assignee:
AVEO Pharmaceuticals, Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/53 (2006.01);
U.S. Cl.
CPC ...
Abstract
A diagnostic method for predicting whether a human tumor will be sensitive or resistant to treatment with tivozanib (AV-951) is disclosed. The method is based on measurement of macrophage content in a tissue sample from a tumor. Measurement of macrophage content can be based on analysis of macrophage marker gene expression, e.g., by RNA analysis or immunohistochemistry.