The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 15, 2010
Filed:
Sep. 16, 2005
Alicia Santos Savio, Ciudad de La Habana, CU;
Ania Cabrales Rico, Ciudad de La Habana, CU;
Osvaldo Reyes Acosta, Ciudad de La Habana, CU;
Haydee Geronimo Perez, Ciudad de La Habana, CU;
Celia Aurora Arrieta Aguero, Ciudad de La Habana, CU;
Silvio Ernesto Perea Rodriguez, Ciudad de La Habana, CU;
Alicia Santos Savio, Ciudad de La Habana, CU;
Ania Cabrales Rico, Ciudad de La Habana, CU;
Osvaldo Reyes Acosta, Ciudad de La Habana, CU;
Haydee Geronimo Perez, Ciudad de La Habana, CU;
Celia Aurora Arrieta Aguero, Ciudad de La Habana, CU;
Silvio Ernesto Perea Rodriguez, Ciudad de La Habana, CU;
Centro de Ingenieria Genetica y Biotecnologia, C. Habana, CU;
Abstract
Current invention is related to the molecular pharmacology branch particularly to a peptide belonging to the Interleukin-15 sequence (IL-15) which is able to inhibit IL-15 biological activity, analogues or mimetic of such peptides. In the current invention it is shown that the peptide inhibits both IL-15-induced T cells proliferation upon binding to the IL15 receptor a subunit (IL15Rα) and TNFα-mediated apoptosis. Besides, this invention is related to the use of this peptide in the treatment of several pathologies where aberrant IL-15 or IL-15Rα expression is associated to the disease progression.