The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 08, 2010
Filed:
Dec. 22, 2005
Andreas Hendrikus Maria DE Vries, Maastricht, NL;
Johannes Gerardus DE Vries, Maastricht, NL;
Friso Bernard Jan Van Assema, Geleen, NL;
Ben DE Lange, Munstergeleen, NL;
Daniel Mink, Eupen, BE;
David John Hyett, Sittard, NL;
Peter Johannes Dominicus Maas, Puth, NL;
Andreas Hendrikus Maria De Vries, Maastricht, NL;
Johannes Gerardus De Vries, Maastricht, NL;
Friso Bernard Jan Van Assema, Geleen, NL;
Ben De Lange, Munstergeleen, NL;
Daniel Mink, Eupen, BE;
David John Hyett, Sittard, NL;
Peter Johannes Dominicus Maas, Puth, NL;
DSM IP Assets B.V., Heerlen, NL;
Abstract
The present invention relates to a process for the preparation of an enantiomerically enriched optionally substituted indoline-2-carboxylic acid or a salt thereof, wherein an enantiomerically enriched chiral ortho-X-substituted phenylalanine compound, wherein X is a leaving group, is subjected to cyclisation, preferably at a temperature of below about 140° C., upon formation of the enantiomerically enriched indoline-2-carboxylic acid compound.