The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 08, 2010
Filed:
Apr. 02, 2005
Wojciech Szczepek, Warsaw, PL;
Dorota Samson-lazinska, Warsaw, PL;
Bogdan Zagrodzki, Warsaw, PL;
Magdalena Glice, Warsaw, PL;
Wioleta Maruszak, Warsaw, PL;
Katarzyna Korczak, Warsaw, PL;
Ryszard Modzelewski, Warsaw, PL;
Marta Lawecka, Warsaw, PL;
Lukasz Kaczmarek, Warsaw, PL;
Wieslaw Szelejewski, Warsaw, PL;
Urszula Fraczek, Marki, PL;
Piotr Cmoch, Warsaw, PL;
Wojciech Szczepek, Warsaw, PL;
Dorota Samson-Lazinska, Warsaw, PL;
Bogdan Zagrodzki, Warsaw, PL;
Magdalena Glice, Warsaw, PL;
Wioleta Maruszak, Warsaw, PL;
Katarzyna Korczak, Warsaw, PL;
Ryszard Modzelewski, Warsaw, PL;
Marta Lawecka, Warsaw, PL;
Lukasz Kaczmarek, Warsaw, PL;
Wieslaw Szelejewski, Warsaw, PL;
Urszula Fraczek, Marki, PL;
Piotr Cmoch, Warsaw, PL;
Instytut Farmaceutyczny, Warsaw, PL;
Abstract
This invention relates to the methanesulfonic acid addition salts of Imatinib and to the synthesis thereof. In particular, this invention relates to the synthesis of crystalline α-form of Imatinib methanesulfonate. Furthermore, the invention is directed to a novel acid addition salt of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-[(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]benzamide with two molecules of methanesulfonic acid and to the polymorphic forms thereof, as well as to their pharmaceutical compositions.