The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 08, 2010

Filed:

Nov. 17, 2004
Applicants:

Rudolf Moser, Schaffhausen, CH;

Viola Groehn, Dachsen, CH;

Andreas Schumacher, Efringen-Kirchen, DE;

Pierre Martin, Rheinfelden, CH;

Dirk Spielvogel, Freiburg, DE;

Inventors:

Rudolf Moser, Schaffhausen, CH;

Viola Groehn, Dachsen, CH;

Andreas Schumacher, Efringen-Kirchen, DE;

Pierre Martin, Rheinfelden, CH;

Dirk Spielvogel, Freiburg, DE;

Assignees:

BioMarin Pharmaceutical Inc., Novato, CA (US);

Merck Eprova AG, Schaffhausen, CH;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 487/00 (2006.01); C07D 491/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

Process for the preparation of tetrahydrobiopterin from neopterin and/or 6-substituted pterins with an improved yield and a high stereoselectivity. Also disclosed herein are novel individual intermediates prepared in the preparation of tetrahydrobiopterin, such as selectively protected neopterin useful for the preparation of tetrahydrobiopterin.


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