Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof

Abstract

The present invention provides nitrogen-containing fused cyclic derivatives represented by the following general formula or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications or obesity, in the formula one of Rand Rrepresents a group represented by the following general formula (S) (in which Rand Rrepresent H, OH, a halogen atom, etc.; Q represents an alkylene group etc.; and ring A represents an aryl group etc.), and the other represents H, OH, an amino group, etc.; Rand Rrepresent H, OH, an amino group, a halogen atom, and an optionally substituted alkyl group, etc.; Arepresents O, S, etc.; Arepresents CH or N; G represents a group represented by the following general formula (G-1) or (G-2) (Erepresents H, F or OH; and Erepresents H, F, a methyl group, etc.), and pharmaceutical compositions comprising the same, and pharmaceutical uses thereof.