The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 01, 2010
Filed:
Mar. 21, 2005
Applicants:
William A. Kinney, Newtown, PA (US);
Xuehai Zhang, East Norriton, PA (US);
Ronald Michalak, Congers, NY (US);
Inventors:
William A. Kinney, Newtown, PA (US);
Xuehai Zhang, East Norriton, PA (US);
Ronald Michalak, Congers, NY (US);
Assignee:
Ohr Pharmaceutical Inc., New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07J 41/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective sulfonation of a fused ring system. The fused ring system base can be, for example, a steroid ring base. The aminosterol compounds are effective as, among others, antibiotics, antiangiogenic agents and NHE3 inhibitors.