The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 01, 2010
Filed:
Feb. 16, 2006
Wallace C. Pringle, Guilford, CT (US);
John M. Peterson, Durham, CT (US);
Linghong Xie, Guilford, CT (US);
Ping GE, Durham, CT (US);
Yang Gao, Madison, CT (US);
Joseph W. Ochterski, Middlefield, CT (US);
Jiong Lan, Moraga, CA (US);
Wallace C. Pringle, Guilford, CT (US);
John M. Peterson, Durham, CT (US);
Linghong Xie, Guilford, CT (US);
Ping Ge, Durham, CT (US);
Yang Gao, Madison, CT (US);
Joseph W. Ochterski, Middlefield, CT (US);
Jiong Lan, Moraga, CA (US);
Neurogen Corporation, Branford, CT (US);
Abstract
Thiazole amides, imidazole amides and related analogues of the Formula: are provided, in which variables are as described herein. Such compounds may be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) and other disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).