The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 01, 2010
Filed:
Apr. 03, 2008
Steven Paul Hanlon, Bottmingen, CH;
Hans Iding, Rheinfelden, DE;
Ernst Kupfer, Zurich, CH;
Roumen Nikolaev Radinov, West Caldwell, NJ (US);
Lianhe Shu, Livingston, NJ (US);
Ping Wang, Nutley, NJ (US);
Steven Paul Hanlon, Bottmingen, CH;
Hans Iding, Rheinfelden, DE;
Ernst Kupfer, Zurich, CH;
Roumen Nikolaev Radinov, West Caldwell, NJ (US);
Lianhe Shu, Livingston, NJ (US);
Ping Wang, Nutley, NJ (US);
Hoffman-La Roche Inc., Nutley, NJ (US);
Abstract
The present invention relates to biocatalytic asymmetric reduction for the preparation of 2-amino-[5-(1-hydroxy-2-hydroxy or halogen-ethyl)]-pyrazine derivatives of the formula wherein R is lower alkylcarbonyl or an amino protecting group and Ris hydroxy or halogen. The compounds are key intermediates in the manufacture of a glucokinase activator.