The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 01, 2010
Filed:
May. 28, 2004
Daniel E. Afar, Pacific Palisades, CA (US);
Rene S. Hubert, Los Angeles, CA (US);
Arthur B. Raitano, Los Angeles, CA (US);
Douglas Saffran, Encinitas, CA (US);
Steven Chappell Mitchell, Gurnee, IL (US);
Daniel E. Afar, Pacific Palisades, CA (US);
Rene S. Hubert, Los Angeles, CA (US);
Arthur B. Raitano, Los Angeles, CA (US);
Douglas Saffran, Encinitas, CA (US);
Steven Chappell Mitchell, Gurnee, IL (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
Described is a family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed 'STEAP' (ixransmembranepithelialntigen of therostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family is STEAP-1, which appears to be a type IIIa membrane protein. STEAP-1 is a 339 amino acid protein. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.