The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 2010
Filed:
Mar. 12, 2008
Robert Dancer, Hvidovre, DK;
Hans Petersen, Vanlose, DK;
Ole Nielsen, Valby, DK;
Michael Harold Rock, Hvidovre, DK;
Helle Eliasen, Koge, DK;
Ken Liljegren, Vaerlose, DK;
Robert Dancer, Hvidovre, DK;
Hans Petersen, Vanlose, DK;
Ole Nielsen, Valby, DK;
Michael Harold Rock, Hvidovre, DK;
Helle Eliasen, Koge, DK;
Ken Liljegren, Vaerlose, DK;
H. Lundbeck A/S, Valby-Copenhagen, DK;
Abstract
The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzo-furancarbonitrile, formulations of said base, a process for the preparation of purified salts of escitalopram, such as the oxalate, using the base, the salts obtained by said process and formulations containing such salts, and a process for the preparation of purified escitalopram free base or salts of escitalopram, such as the oxalate, using the hydrobromide, the salts obtained by said process and formulations containing such salts. Finally the present invention relates to an orodispersible tablet having a hardness of at least 22 N and an oral-disintegration time of less than 120 s and comprising an active pharmaceutical ingredient adsorbed onto a water soluble filler wherein the active pharmaceutical ingredient has a melting point in the range of 40-100° C., as well as a method for making such an orodispersible tablet.