The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 2010
Filed:
Jul. 26, 2006
Noel P. Bouck, Occidental, CA (US);
David W. Dawson, Los Angeles, CA (US);
Paul R. Gillis, San Francisco, CA (US);
Olga Volpert, Wilmette, IL (US);
Susan E. Crawford, Burr Ridge, IL (US);
Veronica M. Stellmach, Chicago, IL (US);
Noel P. Bouck, Occidental, CA (US);
David W. Dawson, Los Angeles, CA (US);
Paul R. Gillis, San Francisco, CA (US);
Olga Volpert, Wilmette, IL (US);
Susan E. Crawford, Burr Ridge, IL (US);
Veronica M. Stellmach, Chicago, IL (US);
Northwestern University, Chicago, IL (US);
Abstract
The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of PEDF within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.