The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 2010
Filed:
Jan. 26, 2006
Applicants:
Eicke Latz, Boston, MA (US);
Alberto Visintin, Worcester, MA (US);
Douglas T. Golenbock, Wellesley, MA (US);
Inventors:
Eicke Latz, Boston, MA (US);
Alberto Visintin, Worcester, MA (US);
Douglas T. Golenbock, Wellesley, MA (US);
Assignee:
University of Massachusetts, Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/52 (2006.01); G01N 33/53 (2006.01); G01N 33/557 (2006.01); G01N 33/566 (2006.01); G01N 33/58 (2006.01);
U.S. Cl.
CPC ...
Abstract
TLR9 is localized to endoplasmic reticulum and upon stimulation with a TLR9 ligand, is transported to a tubular lysosomal compartment as is CpG-DNA. Furthermore, it is shown that TLR9 and CpG-DNA directly bind. It was also found that the MyD88 translocates in response to activation of TLR9-mediated signaling. Methods of identifying compounds that affect translocation and activity of TLR9 and MyD88 are described.