The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 2010
Filed:
Jul. 13, 2006
Shimon Chernyak, Yokneam Yllit, IL;
Martin Zarbov, Kiriat Haim, IL;
Daniella Gutman, Rishon Lezion, IL;
Shimon Chernyak, Yokneam Yllit, IL;
Martin Zarbov, Kiriat Haim, IL;
Daniella Gutman, Rishon Lezion, IL;
Taro Pharmaceuticals U.S.A., Inc., Hawthorne, NY (US);
Abstract
A method for producing a 6α-fluorinated corticosteroid or derivative thereof by reacting a 17-hydroxy-21-ester epoxide of Formula II with a stereoselective fluorinating agent to stereoselectively form a 21-ester-17-hydroxy 6α-fluorinated compound of Formula VII Rcan be OC(O)—R; Rcan be C(O)—R; Rcan be H or R. Each Rmay be the same or different and is independently selected from (C)alkyl, aryl and heteroaryl. The dashed line can be a single or a double bond. Rmay be, for example, acetyl; Rmay be, for example, alpha or beta methyl; Rmay be, for example, acetate or propionate, The stereoselective fluorinating agent used in the reaction may be, for example, a fluoropyridinium or fluoroquinuclidium compound, for example, Selectfluor®.