The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 18, 2010
Filed:
Feb. 23, 2005
Michael E. Jung, Los Angeles, CA (US);
Samedy Ouk, Los Angeles, CA (US);
Charles L. Sawyers, Los Angeles, CA (US);
Charlie D. Chen, Los Angeles, CA (US);
Derek Welsbie, Northridge, CA (US);
Michael E. Jung, Los Angeles, CA (US);
Samedy Ouk, Los Angeles, CA (US);
Charles L. Sawyers, Los Angeles, CA (US);
Charlie D. Chen, Los Angeles, CA (US);
Derek Welsbie, Northridge, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
A modest (2-5 fold) increase in androgen receptor (AR) mRNA is the only expression change consistently associated with developing resistance to antiandrogen therapy. Increased levels of AR confer resistance to anti-androgens by amplifying signal output from low levels of residual ligand and altering the normal response to antagonists. This invention provides cell based assays for use in the examination of new therapeutic modalities and provides for the design of novel antiandrogen compounds.