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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7718644 B1

PDFFull Text
Date of Patent:
May. 18, 2010

Filed:

Mar. 25, 2004

Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (ryr2) and uses thereof

Applicants:

Andrew Robert Marks, Larchmont, NY (US);

Donald W. Landry, New York, NY (US);

Shixian Deng, White Plains, NY (US);

Zhen Zhuang Cheng, Elmhurst, NY (US);

Inventors:

Andrew Robert Marks, Larchmont, NY (US);

Donald W. Landry, New York, NY (US);

Shixian Deng, White Plains, NY (US);

Zhen Zhuang Cheng, Elmhurst, NY (US);

Assignee:

The Trustees of Columbia University in the City of New York, New York, NY (US);

Attorney:

Winston & Strawn LLP

Primary Examiner:

Frederick Krass

Assistant Examiner:

Benjamin Packard

Int. Cl.
CPC ...
A01N 43/00 (2006.01); A61K 31/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention provides methods for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject. The present invention further provides methods for treating and preventing atrial and ventricular cardiac arrhythmias, heart failure, and exercise-induced sudden cardiac death in a subject. Additionally, the present invention provides use of JTV-519 in a method for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject who has, or is a candidate for, atrial fibrillation. Also provided are uses of 1,4-benzothiazepine derivatives in methods for treating and preventing atrial and ventricular cardiac arrhythmias and heart failure in a subject, and for preventing exercise-induced sudden cardiac death. The present invention also provides methods for identifying agents for use in treating and preventing atrial fibrillation and heart failure, and agents identified by these methods.

Find Patent Forward Citations

Marks, Andrew. (2010). Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (ryr2) and uses thereof (U.S. Patent No. 7718644). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/7718644

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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